How Spravato Works
A comprehensive guide to esketamine therapy and what makes it different from traditional antidepressants.
The Science Behind Spravato
A Different Approach to Depression
Traditional antidepressants work by affecting serotonin, norepinephrine, or dopamine levels in the brain. While effective for many, these medications don't work for everyone—and they can take 4-6 weeks to show results.
Spravato works differently. It targets the glutamate system, the brain's most abundant neurotransmitter. By blocking NMDA receptors, it triggers a cascade of changes that help restore synaptic connections damaged by chronic stress and depression. This can lead to rapid improvement in mood—sometimes within hours.
Rapid Action
Unlike traditional antidepressants, Spravato can provide relief within hours to days, not weeks. This is crucial for patients in crisis.
Neuroplasticity
Spravato promotes the growth of new neural connections (synaptogenesis), helping to reverse damage caused by chronic depression.
Who Is Spravato For?
Spravato is specifically approved for adults with:
Treatment-Resistant Depression (TRD)
You've tried at least 2 different antidepressant medications at adequate doses and duration without sufficient improvement.
MDD with Suicidal Ideation
You have major depressive disorder with acute suicidal thoughts or behaviors requiring rapid intervention.
What to Expect During Treatment
Before Your Session
- Don't eat for 2 hours before treatment
- Don't drink liquids for 30 minutes before
- Arrange transportation (you cannot drive after)
- Avoid nasal decongestants on treatment day
During Your Session (~2 hours)
Self-Administration
You administer the nasal spray yourself under guidance
Monitoring
We check your blood pressure and observe your response
Rest
Relax in our comfortable treatment room
Possible Side Effects
Side effects typically occur during the session and resolve before you leave:
The Treatment Process
From your first consultation to ongoing care
Initial Consultation
Meet with our psychiatrist to discuss your depression history, previous treatments, and determine if Spravato is right for you. We'll review your medical history and answer all your questions.
Insurance Verification
Our team verifies your insurance benefits and handles prior authorization. We'll explain your coverage, copays, and any available assistance programs before treatment begins.
Treatment Sessions
Receive Spravato treatment in our comfortable, supervised environment. Sessions last about 2 hours, during which you'll self-administer the nasal spray while our team monitors you.
Ongoing Care
Continue with regular sessions based on your personalized treatment plan. We monitor your progress, adjust treatment as needed, and support you throughout your recovery journey.
Ready to Learn More?
Schedule a consultation to discuss whether Spravato is right for your situation. We'll review your history and answer all your questions.
Or call us directly
(678) 437-1659